Medical Drug Interactions

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When two or more drugs are taken at the same time a drug interaction can happen. These interactions can likewise take place between pharmaceutical drugs and herbal medications and even between drugs and foods. The greater the number of drugs and/or herbs taken the greater the possibility of interactions.

What are drug interactions?

An interaction is a normally unwanted outcome of integrating two or more chemicals within the body. Sometimes it includes the result of direct chemical interactions (such as when 2 chemicals combine to create a 3rd and unplanned chemical) and often it connects to the impact on the body triggered by treatment with more than one drug at a time, such as two drugs affecting the very same system, although the drugs do not themselves integrate to develop yet another drug. Drug interactions are very common and while many have only minor effects they can be quite hazardous, even deadly.

Drug interactions are typically characterised by one of two general results. One involves the drugs improving their results (that is potentiating or interacting to have a stronger action). For instance, drugs that are used to thin the blood and reduce the possibility that the blood will thicken (anticoagulants) are frequently affected by this problem. Combined treatments will work together and the blood could become so thin that bleeding might occur and it would be hard for the blood to form an embolism to stop the bleeding. One example would be taking aspirin while being treated with heparin because both are recognized anticoagulants. There are likewise herbs that have an anticoagulant result and these can communicate with medical anticoagulants. These herbs consist of cayenne and ginger which are specific herbal anticoagulants. There are other herbs and vitamins that have an anticoagulant result – these consist of ginkgo biloba, garlic and vitamin E. The other basic impact naturally is simply the reverse. This involves the drugs working against each other causing them to be less efficient.

How do the drug interactions happen?

There are many ways that the interactions can take place. The main ways are covered listed below.

Physical or chemical incompatibility – This normally takes place when drugs are mixed in the liquid form. If there is a physical incompatibility then there is frequently a precipitate – solid parts begin forming in the mix. An example is diazepam (Valium) – a common sedative. In the liquid kind it will not blend well with water. This is a physical incompatibility. With a chemical incompatibility a chemical reaction can occur which alters the drug. For example, the liquid form of penicillin (an antibiotic) will be inactivated if it is mixed with aminoglycosides (another group of antibiotics) such as streptomycin.

Nevertheless, this type of chemical incompatibility can be helpful. For instance, the drug action of the blood thinner heparin can be reversed by the drug protamine, a drug which binds to and inactivates the heparin. Protamine is therefore used as a particular remedy for a heparin overdose.

Disturbance with the absorption of nutrients in the digestion tract – The rate at which the stomach and intestines work can be affected by various drugs.

For example, when anti-nausea drugs such as metoclopramide (Maxolon, Pramin) are taken, they will accelerate the rate at which the stomach empties. This is essential to understand if, for instance, digitalis (a heart drug) is given as the time that it has to be soaked up in the stomach is reduced and the efficient dose will therefore be lower. If the stomach clearing time is reduced, for instance, with propantheline (an antispasmodic drug) the time spent in the stomach, and thus the absorption of digitalis, will be increased.

Altering of drug metabolism – Some drugs have the ability to stimulate the breaking down of other drugs in the liver.

For instance, barbiturates (anti-anxiety sedatives) are known to do this. When barbiturates are given with oral anticoagulants (blood slimmers) then the dose of the blood slimmers needs to be increased because of the rate at which they will be broken down in the liver. There are lots of examples of where one drug will affect the rate at which another drug is broken down.

Drugs which affect the same body system – This is where two drugs have an impact, which might be planned or otherwise, on the same body system.

For instance, drugs that dull the responses of the brain. These include: alcohol, antihistamines, sedatives and pain reliever. The results of one will tend to make the other stronger. This can likewise work by a drug lowering the result of another drug. For instance, drug doses of vitamin K works against the impacts of oral blood thinners.

Drug and food interactions – The value of these interactions must not be ignored.

For instance, Monoamine oxidase inhibitors (MAOIs) (such as Phenelzine, Iproniazid, Tranylcypromine) are antidepressant drugs that communicate with foods rich in tyramine. The outcome can be a quick and extended rise in the blood pressure. Foods that have to be avoided consist of: avocados, cheese, spirits and wine, marinaded herring, beef extracts and broad beans. Some over-the-counter drugs such as cold solutions and nasal decongestants can have a similar interaction with the MAOIs.

The Unknown

There are numerous ways that drugs can interact with each other to either enhance or reduce their effect. This suggests that the way a medical drug will work in the body is rather unidentified – specifically if more than one or two medical drugs are used at the same time. Medical drugs are toxic chemicals and contrary to popular opinion motivated by drug prescribers and pharmaceutical companies alike, we normally do not know or comprehend the real impact of these drugs upon the body.

When two or more drugs are taken, complicated chemicals comprised of each drug plus the resulting effects of their combination are presented to the body – this indicates that the body has a lot of toxicity to eliminate. The best guidance is to only take medical drugs if they are absolutely necessary and after that only take them for as short an amount of time as possible. In many/most cases alternatives to medical drugs are readily available. Amazingly, many people are recommended numerous drugs over time and end up taking a lot more than two drugs every day. The fact is, nobody knows the genuine impacts this scenario will cause however we do understand that preventable disease and death prevail results.

Conclusion buy modalert

It is best to deal with improving your health and preventing the start of illness. Guarantee that your body is as devoid of contaminants as you can. Having stated these things though it is very important that if you are currently taking medical drugs you need to go over possible changes with your health professional. You might be a good idea to look for a consultation but do not just stop your medication without particular expert suggestions.

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